In Situ Hybridization Find information on In Situ Hybridization. In situ hybridization is a form of localizing a specific sequence or target through the use of labeled complementary probes that hybridized (bind) to a specific DNA or RNA sequence in a specimen, which can either be a tissue section, such as an in situ component or the entire tissue, as in plants or embryos. The probes that are used can either be complementary DNA or RNA strands. Insituhybridization.com~Site InfoWhoisTrace RouteRBL Check